MOTS-c
A mitochondrial-derived peptide studied in mitonuclear communication, AMPK-associated signaling, metabolic stress response, and cellular energy-homeostasis models.
Purity Verified by COA
Research Use Only
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Research at a glance
Stable compound identity and handling reference. Confirm lot-specific values against the vial label and available batch record.
MOTS-c
- CAS number
- 1627580-64-6
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.59 g/mol
- Form
- Lyophilized powder
Storage
Store sealed, protected from heat, light, and moisture. For long-term storage, follow the lot-specific COA, label, and institutional protocol. Avoid repeated freeze-thaw cycles after preparation unless validated in the research protocol.
Lot-specific records
Batch-specific - verify availability in the COA library
Open COA librarySelected research sources
Curated literature, verified identity records, and clearly labeled live indexes for the named compound or formulation. None tests this batch or establishes an intended use.
MOTS-c and metabolic homeostasis
PUBMED · PMID 25738459Cell and mouse experiments identified MOTS-c as a mitochondrial-derived peptide associated with AMPK signaling and metabolic homeostasis.
Open original source Verified identity recordMOTS-c compound identity
PUBCHEM | CID 146675088PubChem provides the public compound identity and structure record. Lot-specific form and purity must still be confirmed against the batch documentation.
Open identity record Live literature indexBrowse PubMed for MOTS-c
PUBMED | LIVE SEARCHThis opens a live literature search. Results can concern other formulations and do not test this product or batch.
Browse literature indexResearch overview
MOTS-c is supplied as a research-grade material for qualified laboratory use only.
Batch-specific documentation should be reviewed before use. Match vial label, fill amount, SKU, and lot number to the corresponding COA documentation.
Description
What is MOTS-c?
MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. It is studied as a signaling peptide involved in mitochondrial-nuclear communication and cellular adaptation to metabolic stress.
Researchers use MOTS-c in models examining energy homeostasis, AMPK-associated pathways, mitochondrial signaling, and stress-response biology.
Mechanism of Action / Research Focus
MOTS-c is commonly investigated in relation to metabolic-stress signaling and transcriptional responses connected to mitochondrial function. Studies often examine AMPK-associated pathways and adaptive responses to nutrient or oxidative stress.
Because MOTS-c is positioned at the intersection of mitochondrial genetics and cellular signaling, it is useful in models connecting mitochondrial function to systemic metabolic endpoints.
Common Research Applications
Application Areas
- Mitochondrial signaling and mitonuclear communication
- Cellular stress-response assays
- AMPK-associated metabolic pathway research
- Energy homeostasis and metabolic biology models
Research Comparison
| Research tool | Primary focus | Research endpoint examples |
|---|---|---|
| SS-31 | Cardiolipin and inner mitochondrial membrane biology. | Respiration, oxidative stress, mitochondrial energetics. |
| MOTS-c | Mitochondrial-derived peptide signaling. | Mitonuclear communication, AMPK-associated signaling, metabolic stress. |
| NAD+ | Redox coenzyme and NAD-dependent enzyme systems. | NAD+/NADH balance, sirtuin/PARP pathways, cellular energy. |
| Glutathione | Thiol redox and antioxidant defense. | GSH/GSSG ratios, ROS response, detoxification pathways. |
Certificate of Analysis (COA)
Applicable lots should be supported by batch-specific analytical documentation. Before beginning work, verify product identity, purity, fill amount, lot number, and storage requirements against the COA and product label.
MOTS-c FAQs
What makes MOTS-c unusual?
It is a mitochondrial-derived peptide, which makes it relevant to mitonuclear signaling research.
Is MOTS-c sold for consumer use?
No. It is provided only for laboratory research use.
What documentation matters most?
Identity, purity, fill amount, and lot-specific analytical verification.
Selected Research & Chemical References
Chemical Information
| Product | MOTS-c |
|---|---|
| Synonyms | Mitochondrial open reading frame of the 12S rRNA-c |
| CAS Number | 1627580-64-6 |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | 2174.59 g/mol |
| Form | Lyophilized powder |
| Contents | 10mg, 40mg fill amount(s), supplied as lyophilized powder in sealed research vial format unless otherwise stated on the label. |
| Research Notes | Researchers are responsible for supplying compatible diluent, sterile technique supplies, and protocol-specific materials. Compatibility should be validated before any study. |
| Storage | Store sealed, protected from heat, light, and moisture. For long-term storage, follow the lot-specific COA, label, and institutional protocol. Avoid repeated freeze-thaw cycles after preparation unless validated in the research protocol. |
Shipping Information
Orders are fulfilled from domestic inventory when available. Shipping options, carrier service, and delivery estimates are shown at checkout and are subject to inventory status, cutoff times, weather, holidays, and carrier performance.
For larger research quantities or lot-specific documentation requests, contact Aqua Biolabs support before ordering.
Research Use & Compliance
Aqua Biolabs products are intended for laboratory research use only. Products are not drugs, foods, dietary supplements, cosmetics, medical devices, or consumer products.
Products are not intended for human consumption, injection, veterinary use, diagnostic use, therapeutic use, food use, cosmetic application, or household use. Purchasers are responsible for compliance with all applicable laws, institutional requirements, and research safety protocols.
