Semaglutide
A long-acting GLP-1 receptor agonist research peptide studied in incretin signaling, glucose-homeostasis models, appetite-pathway research, and metabolic regulation studies.
Purity Verified by COA
Research Use Only
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Research at a glance
Stable compound identity and handling reference. Confirm lot-specific values against the vial label and available batch record.
Semaglutide
- CAS number
- 910463-68-2
- Molecular formula
- C187H291N45O59
- Molecular weight
- 4113.58 g/mol
- Form
- Lyophilized powder
Storage
Store sealed, protected from heat, light, and moisture. For long-term storage, follow the lot-specific COA, label, and institutional protocol. Avoid repeated freeze-thaw cycles after preparation unless validated in the research protocol.
Lot-specific records
Batch-specific - verify availability in the COA library
Open COA librarySelected research sources
Curated literature, verified identity records, and clearly labeled live indexes for the named compound or formulation. None tests this batch or establishes an intended use.
Once-weekly semaglutide in adults with obesity
PUBMED · PMID 33567185The STEP 1 trial of a pharmaceutical semaglutide formulation reported greater weight reduction than placebo and more frequent gastrointestinal events.
Open original source Peer-reviewed publicationSemaglutide 2.4 mg STEP trial review
DOI.ORGReview the original source for its methods, study population or model, endpoints, limitations, and reported findings.
Open original source Peer-reviewed publicationOnce-weekly semaglutide in adults with overweight or obesity
DOI.ORGReview the original source for its methods, study population or model, endpoints, limitations, and reported findings.
Open original sourceResearch overview
Semaglutide is supplied as a research-grade material for qualified laboratory use only.
Batch-specific documentation should be reviewed before use. Match vial label, fill amount, SKU, and lot number to the corresponding COA documentation.
Description
What is Semaglutide?
Semaglutide is a synthetic GLP-1 analog used in research on incretin receptor signaling. Its design includes structural modifications that improve resistance to enzymatic degradation and extend receptor activity compared with native GLP-1.
As a single-pathway GLP-1 research tool, semaglutide is commonly used to isolate GLP-1 receptor effects before comparing them with dual or triple agonist compounds.
Mechanism of Action / Research Focus
In laboratory models, semaglutide is studied for GLP-1 receptor activation and downstream effects on glucose-dependent insulin signaling, glucagon modulation, gastric-emptying endpoints, and central appetite-regulation pathways.
Its long-acting design makes it relevant in time-course experiments where researchers need sustained GLP-1 receptor engagement and reproducible incretin signaling across controlled models.
Common Research Applications
Application Areas
- GLP-1 receptor pharmacology
- Incretin and glucose-regulation research
- Metabolic signaling and energy-balance models
- Comparative studies with dual and triple agonist peptides
Research Comparison
| Research compound | Primary receptor focus | Common research context |
|---|---|---|
| Semaglutide | GLP-1 | Single-incretin pathway research; glucose and appetite-signaling models. |
| Tirzepatide | GIP + GLP-1 | Dual-incretin research; insulin-response and metabolic regulation models. |
| Retatrutide | GIP + GLP-1 + glucagon | Triple-pathway research; energy balance, body-composition, and hepatic/metabolic endpoints. |
Certificate of Analysis (COA)
Applicable lots should be supported by batch-specific analytical documentation. Before beginning work, verify product identity, purity, fill amount, lot number, and storage requirements against the COA and product label.
Semaglutide FAQs
Is this a medication?
No. Aqua Biolabs supplies this product strictly for laboratory research use. It is not dispensed as a medication.
How does Semaglutide compare to Tirzepatide and Retatrutide?
Semaglutide is a GLP-1 receptor agonist research compound, while tirzepatide and retatrutide are studied as broader multi-receptor agonists.
Can Aqua Biolabs provide dosing guidance?
No. Aqua Biolabs does not provide dosing, administration, clinical, or treatment guidance.
Selected Research & Chemical References
- Semaglutide 2.4 mg STEP trial review
- Once-weekly semaglutide in adults with overweight or obesity
- PubChem semaglutide record
Chemical Information
| Product | Semaglutide |
|---|---|
| Synonyms | GLP-1 receptor agonist research analog |
| CAS Number | 910463-68-2 |
| Molecular Formula | C187H291N45O59 |
| Molecular Weight | 4113.58 g/mol |
| Form | Lyophilized powder |
| Contents | 10mg fill amount(s), supplied as lyophilized powder in sealed research vial format unless otherwise stated on the label. |
| Research Notes | Researchers are responsible for supplying compatible diluent, sterile technique supplies, and protocol-specific materials. Compatibility should be validated before any study. |
| Storage | Store sealed, protected from heat, light, and moisture. For long-term storage, follow the lot-specific COA, label, and institutional protocol. Avoid repeated freeze-thaw cycles after preparation unless validated in the research protocol. |
Shipping Information
Orders are fulfilled from domestic inventory when available. Shipping options, carrier service, and delivery estimates are shown at checkout and are subject to inventory status, cutoff times, weather, holidays, and carrier performance.
For larger research quantities or lot-specific documentation requests, contact Aqua Biolabs support before ordering.
Research Use & Compliance
Aqua Biolabs products are intended for laboratory research use only. Products are not drugs, foods, dietary supplements, cosmetics, medical devices, or consumer products.
Products are not intended for human consumption, injection, veterinary use, diagnostic use, therapeutic use, food use, cosmetic application, or household use. Purchasers are responsible for compliance with all applicable laws, institutional requirements, and research safety protocols.
