Epitalon
A synthetic tetrapeptide studied in telomerase-associated research, pineal/thymic signaling models, circadian biology, cellular senescence, and longevity-related endpoints.
Purity Verified by COA
Research Use Only
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Research at a glance
Stable compound identity and handling reference. Confirm lot-specific values against the vial label and available batch record.
Epitalon
- CAS number
- 307297-39-8
- Molecular formula
- C14H22N4O9
- Molecular weight
- 390.35 g/mol
- Form
- Lyophilized powder
- Sequence
- Ala-Glu-Asp-Gly
Storage
Store sealed, protected from heat, light, and moisture. For long-term storage, follow the lot-specific COA, label, and institutional protocol. Avoid repeated freeze-thaw cycles after preparation unless validated in the research protocol.
Lot-specific records
Batch-specific - verify availability in the COA library
Open COA librarySelected research sources
Curated literature, verified identity records, and clearly labeled live indexes for the named compound or formulation. None tests this batch or establishes an intended use.
Epithalon and telomere-related measures
PUBMED · PMID 12937682Cultured human fetal fibroblast experiments reported telomerase-subunit expression, enzyme activity, and telomere-length changes.
Open original source PubChem identity recordPubChem Epitalon record
PUBCHEM.NCBI.NLM.NIH.GOVReview the original source for its methods, study population or model, endpoints, limitations, and reported findings.
Open original source Reference recordOverview of Epitalon — IJMS 2025
MDPI.COMReview the original source for its methods, study population or model, endpoints, limitations, and reported findings.
Open original sourceResearch overview
Epitalon is supplied as a research-grade material for qualified laboratory use only.
Batch-specific documentation should be reviewed before use. Match vial label, fill amount, SKU, and lot number to the corresponding COA documentation.
Description
What is Epitalon?
Epitalon, also called Epithalon, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It is used in research involving telomerase-associated biology, telomere maintenance, cellular aging models, pineal signaling, and circadian pathway studies.
Because it is a short, defined peptide, Epitalon is commonly used in controlled cellular and animal models where researchers evaluate age-associated gene-expression, oxidative-stress, and neuroendocrine endpoints.
Mechanism of Action / Research Focus
Epitalon research often focuses on telomerase activity, telomere dynamics, chromosomal stability, oxidative-stress markers, and pineal/thymic signaling pathways.
It is also discussed in models of melatonin regulation and circadian rhythm biology, particularly where age-related changes in pineal endocrine output are being investigated.
Common Research Applications
Application Areas
- Cellular-aging and telomerase-associated research
- Oxidative-stress pathway models
- Circadian and pineal-axis studies
- Short-peptide signaling assays
Research Comparison
| Research compound | Core research focus | Important distinction |
|---|---|---|
| Epitalon | Telomerase, telomere biology, pineal/thymic signaling. | Short tetrapeptide often studied in aging and circadian models. |
| FOXO4-DRI | FOXO4–p53 interaction and senescent-cell models. | D-retro-inverso peptide design; requires careful stereochemical verification. |
| Pinealon | Short peptide signaling in neuronal/pineal research models. | Compact EDR tripeptide with gene-expression research interest. |
Certificate of Analysis (COA)
Applicable lots should be supported by batch-specific analytical documentation. Before beginning work, verify product identity, purity, fill amount, lot number, and storage requirements against the COA and product label.
Epitalon FAQs
What is the sequence of Epitalon?
Epitalon is commonly represented as Ala-Glu-Asp-Gly.
Is Epitalon approved for human use?
No. This product is for laboratory research only.
What references are relevant?
Researchers often review telomerase, telomere, and pineal peptide literature before designing studies.
Selected Research & Chemical References
Chemical Information
| Product | Epitalon |
|---|---|
| Synonyms | Epithalon; AEDG tetrapeptide |
| Sequence | Ala-Glu-Asp-Gly |
| CAS Number | 307297-39-8 |
| Molecular Formula | C14H22N4O9 |
| Molecular Weight | 390.35 g/mol |
| Form | Lyophilized powder |
| Contents | 10mg fill amount(s), supplied as lyophilized powder in sealed research vial format unless otherwise stated on the label. |
| Research Notes | Researchers are responsible for supplying compatible diluent, sterile technique supplies, and protocol-specific materials. Compatibility should be validated before any study. |
| Storage | Store sealed, protected from heat, light, and moisture. For long-term storage, follow the lot-specific COA, label, and institutional protocol. Avoid repeated freeze-thaw cycles after preparation unless validated in the research protocol. |
Shipping Information
Orders are fulfilled from domestic inventory when available. Shipping options, carrier service, and delivery estimates are shown at checkout and are subject to inventory status, cutoff times, weather, holidays, and carrier performance.
For larger research quantities or lot-specific documentation requests, contact Aqua Biolabs support before ordering.
Research Use & Compliance
Aqua Biolabs products are intended for laboratory research use only. Products are not drugs, foods, dietary supplements, cosmetics, medical devices, or consumer products.
Products are not intended for human consumption, injection, veterinary use, diagnostic use, therapeutic use, food use, cosmetic application, or household use. Purchasers are responsible for compliance with all applicable laws, institutional requirements, and research safety protocols.
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