Retatrutide
A 39-amino acid triple agonist peptide studied in GIP, GLP-1, and glucagon receptor signaling, metabolic regulation, energy-expenditure biology, and body-composition research models.
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Research Use Only
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Research at a glance
Stable compound identity and handling reference. Confirm lot-specific values against the vial label and available batch record.
Retatrutide
- CAS number
- 2381089-83-2
- Molecular formula
- C221H342N46O68
- Molecular weight
- 4731.33 g/mol
- Form
- Lyophilized powder
Storage
Store sealed, protected from heat, light, and moisture. For long-term storage, follow the lot-specific COA, label, and institutional protocol. Avoid repeated freeze-thaw cycles after preparation unless validated in the research protocol.
Lot-specific records
Batch-specific - verify availability in the COA library
Open COA librarySelected research sources
Curated literature, verified identity records, and clearly labeled live indexes for the named compound or formulation. None tests this batch or establishes an intended use.
Retatrutide in adults with obesity
PUBMED · PMID 37366315A phase 2 randomized trial of a pharmaceutical retatrutide formulation reported dose-dependent weight reductions and frequent dose-related gastrointestinal adverse events.
Open original source Peer-reviewed publicationTriple–Hormone-Receptor Agonist Retatrutide for Obesity — Phase 2 Trial
DOI.ORGReview the original source for its methods, study population or model, endpoints, limitations, and reported findings.
Open original source Peer-reviewed publicationRetatrutide for metabolic dysfunction-associated steatotic liver disease
DOI.ORGReview the original source for its methods, study population or model, endpoints, limitations, and reported findings.
Open original sourceResearch overview
Retatrutide is supplied as a research-grade material for qualified laboratory use only.
Batch-specific documentation should be reviewed before use. Match vial label, fill amount, SKU, and lot number to the corresponding COA documentation.
Description
What is Retatrutide?
Retatrutide is a synthetic 39-amino-acid research peptide designed for investigation of three metabolically relevant receptor systems: glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon receptor signaling.
Its value in research comes from its multi-pathway profile. Where single-pathway GLP-1 analogs and dual GIP/GLP-1 analogs isolate narrower receptor combinations, retatrutide provides a model for studying incretin and glucagon biology together in controlled experimental systems.
Mechanism of Action / Research Focus
Retatrutide is studied as a triple receptor agonist. In research models, GLP-1 signaling is commonly associated with glucose-dependent insulin response, glucagon modulation, gastric-emptying endpoints, and central appetite-signaling pathways. GIP signaling provides a second incretin pathway relevant to beta-cell response and adipose/metabolic signaling. Glucagon receptor activation adds a distinct energy-expenditure and hepatic-metabolism component.
Because all three receptor systems are engaged in the same research molecule, retatrutide is useful in experiments that compare single-, dual-, and triple-incretin strategies across glucose handling, energy balance, lipid metabolism, body-composition endpoints, and liver-fat pathway models.
Common Research Applications
Application Areas
- GIP, GLP-1, and glucagon receptor pharmacology
- Metabolic regulation and incretin signaling models
- Glucose-handling and insulin-response research endpoints
- Body-composition and energy-expenditure research models
- Liver-fat and metabolic-dysfunction pathway studies
Research Comparison
| Research compound | Primary receptor focus | Common research context |
|---|---|---|
| Semaglutide | GLP-1 | Single-incretin pathway research; glucose and appetite-signaling models. |
| Tirzepatide | GIP + GLP-1 | Dual-incretin research; insulin-response and metabolic regulation models. |
| Retatrutide | GIP + GLP-1 + glucagon | Triple-pathway research; energy balance, body-composition, and hepatic/metabolic endpoints. |
Certificate of Analysis (COA)
Applicable lots should be supported by batch-specific analytical documentation. Before beginning work, verify product identity, purity, fill amount, lot number, and storage requirements against the COA and product label.
Retatrutide FAQs
Is Retatrutide approved for human use?
No. Retatrutide sold by Aqua Biolabs is offered strictly as a research compound and is not for human or veterinary use.
How is Retatrutide different from Semaglutide and Tirzepatide in research?
Semaglutide is studied as a GLP-1 receptor agonist, tirzepatide as a dual GIP/GLP-1 receptor agonist, and retatrutide as a triple GIP/GLP-1/glucagon receptor agonist.
What should be verified before research use?
Researchers should verify vial label, fill amount, lot number, COA, identity, purity, and compatibility with the intended laboratory protocol.
Selected Research & Chemical References
- Triple–Hormone-Receptor Agonist Retatrutide for Obesity — Phase 2 Trial
- Retatrutide for metabolic dysfunction-associated steatotic liver disease
- NCATS GSRS Retatrutide record
Chemical Information
| Product | Retatrutide |
|---|---|
| Synonyms | LY3437943; GIP/GLP-1/glucagon receptor tri-agonist research analog |
| CAS Number | 2381089-83-2 |
| Molecular Formula | C221H342N46O68 |
| Molecular Weight | 4731.33 g/mol |
| Form | Lyophilized powder |
| Contents | 5mg, 10mg, 20mg fill amount(s), supplied as lyophilized powder in sealed research vial format unless otherwise stated on the label. |
| Research Notes | Researchers are responsible for supplying compatible diluent, sterile technique supplies, and protocol-specific materials. Compatibility should be validated before any study. |
| Storage | Store sealed, protected from heat, light, and moisture. For long-term storage, follow the lot-specific COA, label, and institutional protocol. Avoid repeated freeze-thaw cycles after preparation unless validated in the research protocol. |
Shipping Information
Orders are fulfilled from domestic inventory when available. Shipping options, carrier service, and delivery estimates are shown at checkout and are subject to inventory status, cutoff times, weather, holidays, and carrier performance.
For larger research quantities or lot-specific documentation requests, contact Aqua Biolabs support before ordering.
Research Use & Compliance
Aqua Biolabs products are intended for laboratory research use only. Products are not drugs, foods, dietary supplements, cosmetics, medical devices, or consumer products.
Products are not intended for human consumption, injection, veterinary use, diagnostic use, therapeutic use, food use, cosmetic application, or household use. Purchasers are responsible for compliance with all applicable laws, institutional requirements, and research safety protocols.
