FOXO4-DRI
A D-retro-inverso cell-penetrating peptide studied in FOXO4–p53 interaction models, cellular senescence research, apoptosis signaling, and age-associated cell biology.
Purity Verified by COA
Research Use Only
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Research at a glance
Stable compound identity and handling reference. Confirm lot-specific values against the vial label and available batch record.
FOXO4-DRI
- CAS number
- 2460055-10-9
- Molecular formula
- C228H388N86O64
- Molecular weight
- 5358.06 g/mol
- Form
- Lyophilized powder
Storage
Store sealed, protected from heat, light, and moisture. For long-term storage, follow the lot-specific COA, label, and institutional protocol. Avoid repeated freeze-thaw cycles after preparation unless validated in the research protocol.
Lot-specific records
Batch-specific - verify availability in the COA library
Open COA librarySelected research sources
Curated literature, verified identity records, and clearly labeled live indexes for the named compound or formulation. None tests this batch or establishes an intended use.
FOXO4-p53 interference in senescent-cell models
PUBMED · PMID 28340339Cell and mouse experiments found that disrupting FOXO4-p53 interactions induced apoptosis in senescent cells and altered tissue-function measures.
Open original source Verified identity recordFOXO4-DRI compound identity
PUBCHEM | CID 167312269PubChem provides the public compound identity and structure record. Lot-specific form and purity must still be confirmed against the batch documentation.
Open identity record Live literature indexBrowse PubMed for FOXO4-DRI
PUBMED | LIVE SEARCHThis opens a live literature search. Results can concern other formulations and do not test this product or batch.
Browse literature indexResearch overview
FOXO4-DRI is supplied as a research-grade material for qualified laboratory use only.
Batch-specific documentation should be reviewed before use. Match vial label, fill amount, SKU, and lot number to the corresponding COA documentation.
Description
What is FOXO4-DRI?
FOXO4-DRI is a D-retro-inverso peptide designed for research on FOXO4–p53 protein interaction and cellular senescence models.
It is typically discussed in the context of senescent-cell biology, stress-response signaling, p53-related pathways, and age-associated tissue models. It should be handled strictly as a research compound.
Mechanism of Action / Research Focus
FOXO4-DRI is studied for its ability to interfere with FOXO4/p53 interaction in senescence models. Research questions often focus on how altered FOXO4-p53 localization or binding affects senescent-cell viability and apoptotic signaling.
Because this compound is used in sensitive cellular models, experimental design should include appropriate controls and lot-specific analytical verification.
Common Research Applications
Application Areas
- Cellular senescence research
- FOXO4-p53 interaction models
- Stress-response signaling assays
- Apoptosis-associated cell biology studies
Research Comparison
| Research compound | Core research focus | Important distinction |
|---|---|---|
| Epitalon | Telomerase, telomere biology, pineal/thymic signaling. | Short tetrapeptide often studied in aging and circadian models. |
| FOXO4-DRI | FOXO4–p53 interaction and senescent-cell models. | D-retro-inverso peptide design; requires careful stereochemical verification. |
| Pinealon | Short peptide signaling in neuronal/pineal research models. | Compact EDR tripeptide with gene-expression research interest. |
Certificate of Analysis (COA)
Applicable lots should be supported by batch-specific analytical documentation. Before beginning work, verify product identity, purity, fill amount, lot number, and storage requirements against the COA and product label.
FOXO4-DRI FAQs
What does DRI mean?
DRI refers to D-retro-inverso peptide design, a modification strategy used in peptide research.
Is FOXO4-DRI a consumer product?
No. It is supplied strictly for laboratory research use.
What should researchers verify?
Sequence, stereochemistry, purity, lot number, and analytical documentation.
Selected Research & Chemical References
Chemical Information
| Product | FOXO4-DRI |
|---|---|
| Synonyms | FOXO4 D-Retro-Inverso peptide |
| CAS Number | 2460055-10-9 |
| Molecular Formula | C228H388N86O64 |
| Molecular Weight | 5358.06 g/mol |
| Form | Lyophilized powder |
| Contents | 10mg fill amount(s), supplied as lyophilized powder in sealed research vial format unless otherwise stated on the label. |
| Research Notes | Researchers are responsible for supplying compatible diluent, sterile technique supplies, and protocol-specific materials. Compatibility should be validated before any study. |
| Storage | Store sealed, protected from heat, light, and moisture. For long-term storage, follow the lot-specific COA, label, and institutional protocol. Avoid repeated freeze-thaw cycles after preparation unless validated in the research protocol. |
Shipping Information
Orders are fulfilled from domestic inventory when available. Shipping options, carrier service, and delivery estimates are shown at checkout and are subject to inventory status, cutoff times, weather, holidays, and carrier performance.
For larger research quantities or lot-specific documentation requests, contact Aqua Biolabs support before ordering.
Research Use & Compliance
Aqua Biolabs products are intended for laboratory research use only. Products are not drugs, foods, dietary supplements, cosmetics, medical devices, or consumer products.
Products are not intended for human consumption, injection, veterinary use, diagnostic use, therapeutic use, food use, cosmetic application, or household use. Purchasers are responsible for compliance with all applicable laws, institutional requirements, and research safety protocols.
